Diamant K, Fischer G, Schneider C, Lenzinger E, Pezawas L, Schindler S, Eder H
Drug Addiction Outpatient Clinic, Department of General Psychiatry, University Hospital of Vienna, Austria.
Eur Addict Res. 1998 Dec;4(4):198-202. doi: 10.1159/000018953.
In an open study design, 50 opioid-dependent subjects (DSM-IV: 304. 0) were investigated in a gradual detoxification treatment with buprenorphine. The study was performed at the drug addiction outpatient clinic of the Department of General Psychiatry at the University of Vienna. Subjects had to contact the outpatient clinic on a daily basis and buprenorphine was administered according to their clinical status. Withdrawal symptoms were evaluated by applying the WANG scale. Urine samples were screened for drug toxicology to exclude additional consumption. In this investigation buprenorphine was applied sublingually in a free dosage scheme aimed at completing detoxification treatment within 10 days by reducing buprenorphine on a daily basis. A mean daily dosage of 2.3 mg buprenorphine was required by patients on day 1 of the treatment period. The highest mean daily buprenorphine dosage was given on day 2, followed by a daily reduction over the study period. The result of this open study design revealed that a gradual daily reduction of buprenorphine might be a successful alternative outpatient detoxification treatment in opioid-dependent subjects. Compliance was 70%, the reported and evaluated withdrawal symptoms during the study period were moderate.
在一项开放性研究设计中，对50名阿片类药物依赖者（DSM-IV：304.0）进行了丁丙诺啡逐步脱毒治疗的研究。该研究在维也纳大学普通精神病学系的药物成瘾门诊进行。受试者必须每天到门诊就诊，丁丙诺啡根据其临床状况给药。应用王式量表评估戒断症状。对尿样进行药物毒理学筛查以排除额外用药情况。在本研究中，丁丙诺啡采用舌下含服的自由剂量方案，目标是通过每日减少丁丙诺啡用量在10天内完成脱毒治疗。治疗期第1天患者平均每日需要2.3毫克丁丙诺啡。丁丙诺啡平均每日剂量在第2天最高，随后在研究期间每日递减。该开放性研究设计的结果显示，每日逐步减少丁丙诺啡用量可能是阿片类药物依赖者一种成功的门诊脱毒替代治疗方法。依从性为70%，研究期间报告并评估的戒断症状为中度。
