Rogers M S, Arumanayagam M, Fung H, Lau T K
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong.
Gynecol Obstet Invest. 1999;47(1):9-12. doi: 10.1159/000010054.
Significant differences in urinary excretion of N-acetyl-beta-glycosaminidase (NAG) were observed between nulliparous and multiparous patients and between fasted and nonfasted individuals. No significant difference was observed between patients with normal and those with abnormal glucose tolerance. Multiple regression analysis confirmed that the significant independent determinants of NAG/creatinine ratio were age, parity, gestation and fasting state. Significant diurnal variation in urinary NAG/Cr ratio was observed, the highest levels being recorded in early morning fasting specimens, falling in each postprandial specimen and beginning to rise again by midnight. The urinary NAG/Cr ratio is influenced by fasting, parity, gestation and age. More consistent results for prediction of pre-eclampsia are therefore likely to be obtained using fasting (early morning) urine specimens and adjusting cut-off criteria for the other factors.
未生育女性与经产妇之间以及禁食者与非禁食者之间，N - 乙酰 - β - 氨基葡萄糖苷酶（NAG）的尿排泄量存在显著差异。糖耐量正常者与异常者之间未观察到显著差异。多元回归分析证实，NAG/肌酐比值的显著独立决定因素为年龄、产次、妊娠和禁食状态。观察到尿NAG/Cr比值存在显著的昼夜变化，清晨禁食标本中该比值最高，每餐餐后标本中该比值下降，到午夜时又开始上升。尿NAG/Cr比值受禁食、产次、妊娠和年龄的影响。因此，使用禁食（清晨）尿液标本并针对其他因素调整临界值标准，可能会获得更一致的子痫前期预测结果。
