Fujimoto J, Hirose R, Sakaguchi H, Tamaya T
Department of Obstetrics and Gynecology, Gifu University School of Medicine, Tsukasa-machi, Gifu City, Japan.
Oncology. 1998 Dec;55 Suppl 1:53-9. doi: 10.1159/000055259.
Estrogen dependency in uterine endometrial cancers involves complicated tumor biology. A transformed phenotype of uterine endometrial cancers is supported by estrogen-dependent oncogene (c-Ha-ras, c-fos and c-jun) expressions. The relative overexpression of estrogen receptor exon 5 splicing variant and the damaged expression of progesterone receptor A, which belong to a lack of estrogen dependency, are related to metastatic potential. The estrogen-related metastatic processes, detachment, invasion and angiogenesis in some uterine endometrial cancers can be inhibited by progestins.
子宫内膜癌中的雌激素依赖性涉及复杂的肿瘤生物学。雌激素依赖性癌基因（c-Ha-ras、c-fos和c-jun）的表达支持子宫内膜癌的转化表型。雌激素受体外显子5剪接变体的相对过表达以及孕激素受体A的表达受损，这属于雌激素依赖性缺乏，与转移潜能有关。某些子宫内膜癌中与雌激素相关的转移过程，即脱离、侵袭和血管生成，可被孕激素抑制。
