Shepherd G E, Findlay J K, Cooper M J, Allen W R
Aust Vet J. 1976 Aug;52(8):345-8. doi: 10.1111/j.1751-0813.1976.tb09484.x.
A clinical trial involving 359 mares was conducted to ascertain the clinical value of a synthetic prostaglandin analogue (fluprostenol, ICI-81,008) structurally related to PGF2oc for treating mares in prolonged dioestrus. Some 263 mares (73.3%) displayed oestrus within 5 days of a first intramuscular injection of 250 mug fluprostenol and, of those mares later examined for pregnancy, 108 (40%) were found to have conceived during the first induced oestrus. A further 21 mares (8%) cycled normally and conceived to services during the second oestrus. Most (80.3%) of the plasma samples obtained from 242 mares prior to treatment showed a progesterone concentration greater than 1 ng/ml, thereby indicating the presence of functional luteal tissue in the ovaries. The results support earlier observations that most non-pregnant mares which fail to cycle during the breeding season are in a state of prolonged dioestrus rather than anoesturs.
进行了一项涉及359匹母马的临床试验，以确定一种与PGF2α结构相关的合成前列腺素类似物（氟前列烯醇，ICI - 81,008）对治疗处于延长发情间期的母马的临床价值。约263匹母马（73.3%）在首次肌肉注射250微克氟前列烯醇后的5天内出现发情，在那些后来检查是否怀孕的母马中，有108匹（40%）被发现在首次诱导发情期间受孕。另外21匹母马（8%）正常发情并在第二次发情期间受孕。从242匹母马治疗前采集的大多数血浆样本（80.3%）显示孕酮浓度大于1纳克/毫升，从而表明卵巢中存在功能性黄体组织。这些结果支持了早期的观察结果，即大多数在繁殖季节未能发情的未怀孕母马处于延长发情间期状态而非乏情期。
