Orikasa K, Fukushige S, Hoshi S, Orikasa S, Kondo K, Miyoshi Y, Kubota Y, Horii A
Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Japan.
J Hum Genet. 1998;43(4):228-30. doi: 10.1007/s100380050078.
Prostate cancer is a major cause of cancer death among elderly men in America, Europe, and Japan. However, the molecular mechanism of carcinogenesis is not yet well characterized. Frequent loss of heterozygosity (LOH) on chromosome 10q was reported in prostate cancer, and a candidate tumor suppressor gene, PTEN, was isolated on chromosome band 10q23.3. To investigate the genetic alterations of PTEN, we examined 45 primary prostate cancer specimens. LOH at the PTEN locus was observed in two (11.1%) of 18 tumors. However, no mutations were observed in any of the primary prostate cancers. These data suggest that mutation of the PTEN gene does not play a major role in prostate carcinogenesis of Japanese patients.
前列腺癌是美国、欧洲和日本老年男性癌症死亡的主要原因。然而，其致癌的分子机制尚未完全明确。据报道，前列腺癌中10号染色体长臂（10q）常出现杂合性缺失（LOH），并且在10号染色体23.3带分离出一个候选肿瘤抑制基因PTEN。为了研究PTEN的基因改变，我们检测了45例原发性前列腺癌标本。在18个肿瘤中有2个（11.1%）观察到PTEN基因座的LOH。然而，在任何原发性前列腺癌中均未观察到突变。这些数据表明，PTEN基因的突变在日本患者前列腺癌发生过程中并不起主要作用。
