与未涂层支架相比，涂层金属支架释放的地塞米松对犬股动脉内膜增生的影响。
Effect on intimal hyperplasia of dexamethasone released from coated metal stents compared with non-coated stents in canine femoral arteries.
作者信息
Strecker E P, Gabelmann A, Boos I, Lucas C, Xu Z, Haberstroh J, Freudenberg N, Stricker H, Langer M, Betz E
机构信息
Department of Radiology, Diakonissen-Hospital, Karlsruhe, Germany.
出版信息
Cardiovasc Intervent Radiol. 1998 Nov-Dec;21(6):487-96. doi: 10.1007/s002709900309.
PURPOSE
Polymer-coated, dexamethasone (DXM)-releasing stents were tested in order to assess the efficacy of DXM released locally for the prevention of stent restenosis due to intimal hyperplasia.
METHODS
Strecker stents coated with a biodegradable membrane containing DXM were implanted percutaneously into the femoral artery in 14 dogs. The contralateral artery received a conventional non-coated stent serving as control. The drugs are eluted by degradation of the carrier membrane. Follow-up intraarterial digital subtraction angiography (DSA) was obtained at 3, 6, 9, 12, and 24 weeks with subsequent autopsy. Specimens for gross and microscopic pathology were obtained and histomorphometry was performed.
RESULTS
Four of 14 DXM-coated stents showed thrombotic occlusion within the first 3 weeks; ten DXM-coated stents remained patent. At follow-up DSA, DXM-coated stents showed a significantly wider lumen than the non-coated stents. At morphometry there was less intimal hyperplasia over DXM-coated stents than over non-coated stents (p < 0.05).
CONCLUSION
DXM-coated stents reduce neointimal hyperplasia in dogs when compared with non-coated stents.
目的
对聚合物涂层、可释放地塞米松（DXM）的支架进行测试，以评估局部释放的DXM预防内膜增生导致的支架再狭窄的疗效。
方法
将涂有含DXM的可生物降解膜的Strecker支架经皮植入14只犬的股动脉。对侧动脉植入传统的无涂层支架作为对照。药物通过载体膜的降解而洗脱。在3、6、9、12和24周时进行随访动脉内数字减影血管造影（DSA），随后进行尸检。获取大体和显微镜病理标本并进行组织形态计量学分析。
结果
14个DXM涂层支架中有4个在最初3周内出现血栓闭塞；10个DXM涂层支架保持通畅。在随访DSA中，DXM涂层支架显示管腔明显比无涂层支架宽。在形态计量学上，DXM涂层支架上的内膜增生比无涂层支架少（p<0.05）。
结论
与无涂层支架相比，DXM涂层支架可减少犬的新生内膜增生。
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