Yeshaya A, Orvieto R, Kaplan B, Dicker D, Bar-Hava I, Bar J, Ben-Rafael Z
Department of Obstetrics and Gynecology, Rabin Medical Center, Petah Tiqva, Israel.
Eur J Contracept Reprod Health Care. 1998 Sep;3(3):121-3. doi: 10.3109/13625189809051414.
To compare the effect of starting oral contraceptives on the first day of menses with the effect of starting on the day of menses' cessation (but no later than the 5th day following its onset), on the incidence of early breakthrough bleeding.
Oral contraceptives containing 30 micrograms ethinylestradiol and 75 micrograms gestodene were prescribed to 200 consecutive healthy women in whom oral contraceptives were found to be the most suitable method of contraception. In the first 100 women, treatment was started on the 1st day after the onset of menses (Day 1 group), and in the remainder, treatment was started on the day of menses' cessation, but no later than the 5th day following its onset (Flexible group).
The Flexible group had better compliance and a reduced incidence of breakthrough bleeding. No differences were observed between the two groups for age, parity and gravity, or contraceptive failure.
Oral contraceptives may be initiated on the day of menses' cessation, but no later than the 5th day following its onset. This regimen might increase patient compliance and lower the incidence of breakthrough bleeding, probably without adversely affecting contraceptive efficacy.
比较在月经第一天开始服用口服避孕药与在月经结束日（但不晚于月经开始后的第5天）开始服用口服避孕药对早期突破性出血发生率的影响。
对连续200名健康女性开具含30微克炔雌醇和75微克孕二烯酮的口服避孕药，这些女性被认为口服避孕药是最合适的避孕方法。前100名女性在月经开始后的第1天开始治疗（第1天组），其余女性在月经结束日开始治疗，但不晚于月经开始后的第5天（灵活组）。
灵活组的依从性更好，突破性出血的发生率降低。两组在年龄、产次和妊娠情况或避孕失败方面未观察到差异。
口服避孕药可在月经结束日开始服用，但不晚于月经开始后的第5天。这种方案可能会提高患者的依从性并降低突破性出血的发生率，可能不会对避孕效果产生不利影响。
