Determination of small objects from pinhole scintigrams.

This study assessed the possibility of measuring the linear dimensions of small structures using pinhole scintigraphy. A number of glass objects were made with a spherical, cylindrical or conical shape. Their maximum dimensions (diameters and heights) were 3.5-22.5 mm. These glass objects were filled with 131I, placed inside a plastic neck phantom and imaged using a gamma camera equipped with a pinhole collimator. The source-to-collimator distance was varied from 2 to 12 cm. An algorithm for image segmentation (threshold selection) was used to divide the image into object and background. On the segmented image, the number of non-zero pixels in the direction of the principal axes was multiplied by the appropriate calibration factor to obtain the linear dimensions of the object. Spatial resolution of the pinhole collimator, expressed as the full-width at half-maximum (FWHM), varied from 8 to 10 mm for the range of source-to-collimator distances examined. We found that, for dimensions up to 1.5 x FWHM, finite spatial resolution affects the accuracy of measurement. Non-linear correlation between true and calculated dimensions was used to take the latter into account. Our results are now being used to improve quantitation of remnant thyroid tissue masses for the calculation of radioiodine ablation doses.