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作为抗菌剂的稠合吡唑系统的新型合成方法。

A novel synthesis of fused pyrazole systems as antimicrobial agents.

作者信息

Erian A W, el-Gohary S, Manhi F M, Ali F A

机构信息

Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt.

出版信息

Pharmazie. 1998 Nov;53(11):748-51.

PMID:9853356
Abstract

The pyrazolo[3,4-b]pyridine derivatives 3 could be prepared by condensing compounds 1 with the 3-aminopyrazolone derivative 2. The pyrazolo[5,2-b]-1,3-oxazine derivative 11 and polyfunctionally substituted 1,4-dihydropyridines 15, 18 were also synthesized. Some of the obtained compounds were tested for their antimicrobial activity.

摘要

吡唑并[3,4 - b]吡啶衍生物3可通过将化合物1与3 - 氨基吡唑啉酮衍生物2缩合来制备。还合成了吡唑并[5,2 - b]-1,3 - 恶嗪衍生物11以及多官能团取代的1,4 - 二氢吡啶15、18。对部分所得化合物进行了抗菌活性测试。

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