1,2,5-恶二唑氮氧化物衍生物作为缺氧选择性细胞毒素的合成及生物学评价
Synthesis and biological evaluation of 1,2,5-oxadiazole N-oxide derivatives as hypoxia-selective cytotoxins.
作者信息
Monge A, López de Ceráin A, Ezpeleta O, Cerecetto H, Dias E, Di Maio R, González M, Onetto S, Seoane G, Suescun L, Mariezcurrena R
机构信息
Department of Medicinal Chemistry, University of Navarra, Pamplona, Spain.
出版信息
Pharmazie. 1998 Nov;53(11):758-64.
PMID:9853357
Abstract
Synthesis and biological evaluation of new 1,2,5-oxadiazole N-oxide derivatives with potential cytotoxic effects are described. From the series of compounds tested, compounds 2 and 6 proved to be very active, although non-selective.
摘要
本文描述了具有潜在细胞毒性作用的新型1,2,5-恶二唑N-氧化物衍生物的合成及生物学评价。在所测试的一系列化合物中，化合物2和6表现出很高的活性，尽管缺乏选择性。
Zotero 插件