Li H, Matsumoto K, Watanabe H
Department of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University, Japan.
Biol Pharm Bull. 1998 Nov;21(11):1228-30. doi: 10.1248/bpb.21.1228.
The interaction of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonist YM90K with the competitive N-methyl-D-aspartate (NMDA) antagonist CGS19755 or with the NMDA channel blocker MK801 on the spatial memory of rats was examined by the 4-arm-baited radial maze task. When administered alone, these drugs had no effect on the spatial memory. The combination of YM90K and MK801 synergistically disrupted working and reference memories, whereas the combination of YM90K and CGS19755 had no effect. These results indicate that the blockade of the AMPA receptor and NMDA channels produces a synergistic impairment of spatial memory and suggest that interaction between the AMPA and NMDA receptors plays a role in cognitive function.
通过四臂诱饵放射状迷宫任务，研究了α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）拮抗剂YM90K与竞争性N-甲基-D-天冬氨酸（NMDA）拮抗剂CGS19755或与NMDA通道阻滞剂MK801联合使用对大鼠空间记忆的影响。单独给药时，这些药物对空间记忆没有影响。YM90K与MK801联合使用会协同破坏工作记忆和参考记忆，而YM90K与CGS19755联合使用则没有效果。这些结果表明，AMPA受体和NMDA通道的阻断会协同损害空间记忆，并提示AMPA和NMDA受体之间的相互作用在认知功能中起作用。
