Lass A, Peat D, Avery S, Brinsden P
Bourn Hall Clinic, Cambridge, UK.
Hum Reprod. 1998 Nov;13(11):3203-5. doi: 10.1093/humrep/13.11.3203.
The objective of this study was to evaluate the histopathological characteristics of endometrial biopsies taken on the day of oocyte recovery in in-vitro fertilization (IVF) cycles with a satisfactory response to ovulation induction. A group of 33 patients who went through ovulation induction for IVF, and in whom an endometrial polyp was suspected on transvaginal ultrasonography during the monitoring phase, were studied. Following oocyte recovery, hysteroscopy, polypectomy and endometrial curettage were performed. Dating of endometrial glands and stroma was carried out in the tissue not containing the polyps. The total dose of follicle stimulating hormone (FSH), duration of ovulation induction, peak oestradiol and luteinizing hormone (LH) concentrations, thickness of endometrium and number of oocytes were recorded and compared to the endometrial dating of the specimens. In 15 cycles (45.5%), the endometrium was classified as 'in phase' (group I), 'advanced' by 2-4 days in a further 15 (45.5%, group II), and in the remaining three cycles (9%) it was delayed in maturation (group III). Younger age was correlated with advanced staging of the endometrium (r = -0.42; P = 0.015). Women with 'in phase' and 'advanced' maturation were similar in their response to ovulation induction; however, there was a strong correlation between advanced dating of endometrium and number of oocytes retrieved (r = 0.49; P = 0.04). Endometrial staging on the day of oocyte retrieval varied widely in patients treated by the same gonadotrophin-releasing hormone agonist (GnRHa)/FSH protocol for ovulation induction. This difference was not predictable by parameters monitored through the cycles.
本研究的目的是评估在体外受精（IVF）周期中，对排卵诱导反应良好的患者在卵母细胞回收当天进行的子宫内膜活检的组织病理学特征。研究了一组33例接受IVF排卵诱导的患者，这些患者在监测阶段经阴道超声检查怀疑有子宫内膜息肉。卵母细胞回收后，进行宫腔镜检查、息肉切除术和子宫内膜刮除术。对不含息肉的组织进行子宫内膜腺体和间质的分期。记录卵泡刺激素（FSH）的总剂量、排卵诱导的持续时间、雌二醇峰值和促黄体生成素（LH）浓度、子宫内膜厚度和卵母细胞数量，并与标本的子宫内膜分期进行比较。在15个周期（45.5%）中，子宫内膜被归类为“同期”（I组），另外15个周期（45.5%，II组）提前2 - 4天，其余3个周期（9%）成熟延迟（III组）。年龄较小与子宫内膜分期提前相关（r = -0.42；P = 0.015）。“同期”和“提前”成熟的女性对排卵诱导的反应相似；然而，子宫内膜提前分期与回收的卵母细胞数量之间存在强相关性（r = 0.49；P = 0.04）。在接受相同促性腺激素释放激素激动剂（GnRHa）/FSH方案进行排卵诱导的患者中，卵母细胞取出当天的子宫内膜分期差异很大。这种差异无法通过整个周期监测的参数预测。
