Malamitsi-Puchner A, Sarandakou A, Tziotis J, Dafogianni C, Bartsocas C S
Second Department of Obstetrics and Gynecology, University of Athens, Greece.
Pediatr Res. 1998 Dec;44(6):873-5. doi: 10.1203/00006450-199812000-00008.
Diabetes mellitus is characterized by microangiopathy and increased angiogenic response in various organs. Basic fibroblast growth factor (bFGF) as well as vascular endothelial growth factor (VEGF) are both angiogenic and are involved in vascular endothelial cell growth. The purpose of this study was to determine serum levels of bFGF and VEGF, in children and adolescents (youngsters) with type 1 diabetes mellitus, and correlate them with parameters reflecting the severity of the disease. Forty diabetic youngsters without clinical evidence of complications were compared with 30 healthy control subjects (mean age +/- SD, 14.3 +/- 3.6 and 13.8 +/- 3.6 y, respectively). Diabetes duration and metabolic control (expressed by glycosylated Hb) were (mean +/- SD) 6.2 +/- 3.8 y and 9.6 +/- 1.8%, respectively. bFGF and VEGF (pg/mL) were measured in serum samples by enzyme immunoassays, and both were not significantly different between the type 1 diabetes mellitus and the control group (p = 0.952 and p = 0.559, respectively). Restricting the analysis to the type 1 diabetes mellitus group, neither the duration nor the metabolic control of the disease showed any correlation with bFGF and VEGF serum levels, whereas a significantly positive correlation was found between the two examined angiogenic factors both in the diabetic (r = 0.3464, p = 0.025) and the control group (r = 0.4619, p = 0.0013). In conclusion, serum levels of bFGF and VEGF were not found to vary significantly in diabetic youngsters in relation to controls and had no correlation with the duration and metabolic control of the disease. Nevertheless, a positive correlation was found between these two angiogenic factors both in the type 1 diabetes mellitus and the control group.
糖尿病的特征是微血管病变以及各器官血管生成反应增加。碱性成纤维细胞生长因子（bFGF）和血管内皮生长因子（VEGF）都具有血管生成作用，并参与血管内皮细胞生长。本研究的目的是测定1型糖尿病儿童和青少年（年轻人）血清中bFGF和VEGF的水平，并将它们与反映疾病严重程度的参数进行关联分析。将40例无并发症临床证据的糖尿病青少年与30例健康对照者进行比较（平均年龄±标准差分别为14.3±3.6岁和13.8±3.6岁）。糖尿病病程和代谢控制情况（用糖化血红蛋白表示）分别为（平均±标准差）6.2±3.8年和9.6±1.8%。通过酶免疫测定法检测血清样本中的bFGF和VEGF（pg/mL），1型糖尿病组与对照组之间这两者均无显著差异（p值分别为0.952和0.559）。在1型糖尿病组中进行分析时，疾病的病程和代谢控制与bFGF和VEGF血清水平均无相关性，而在糖尿病组（r = 0.3464，p = 0.025）和对照组（r = 0.4619，p = 0.0013）中，所检测的这两种血管生成因子之间均存在显著正相关。总之，未发现糖尿病青少年血清中bFGF和VEGF水平与对照组相比有显著差异，且与疾病的病程和代谢控制无关。然而，在1型糖尿病组和对照组中，这两种血管生成因子之间均存在正相关。
