Pallares-Trujillo J, Lopez-Soriano F J, Argilés J M
Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.
Int J Mol Med. 1998 Jul;2(1):3-15.
Alzheimer's disease, the most common form of senile dementia, affects more than 15 million people world-wide and is characterized by a marked deterioration in memory and all cognitive functions, as a result of a progressive degeneration and loss of cortical and limbic neurons. This process is associated with the presence of both the so-called -amyloid deposits and the cellular neurofibrillary tangles composed mainly of paired helical filaments of aberrantly hyperphosphorylated tau protein. The accumulation of ubiquitin in neurofibrillary tangles and senile plaques (both characteristic of the neuronal abnormalities associated with the disease) is postulated to play a role in the repair mechanism related to neuronal regeneration.
阿尔茨海默病是最常见的老年痴呆形式，全球有超过1500万人受其影响，其特征是记忆和所有认知功能显著衰退，这是由于皮质和边缘神经元进行性退化和丧失所致。这个过程与所谓的β-淀粉样蛋白沉积以及主要由异常高度磷酸化的tau蛋白的双螺旋丝组成的细胞神经原纤维缠结的存在有关。泛素在神经原纤维缠结和老年斑（两者都是与该疾病相关的神经元异常的特征）中的积累被认为在与神经元再生相关的修复机制中起作用。
