Tagashira H, Hamazaki K, Tanaka N, Gao C, Namba M
First Department of Surgery, Institute of Molecular and Cellular Biology, Okayama University Medical School, Okayama 700-8558, Japan.
Int J Mol Med. 1998 Jul;2(1):65-8. doi: 10.3892/ijmm.2.1.65.
Increased expression of nm23/nucleoside diphosphate kinase (NDP kinase) has been reported to be associated with both reduced metastatic potential in breast carcinoma and tumor progression in colon adenocarcinoma and lung adenocarcinoma. We examined effects of expression of nm23-R2 rat NDP kinase alpha isoform on mouse adenocarcinoma cells (Colon 26 line) and found a significant reduction of metastatic potential along with overexpression of c-myc. We also found that the proliferation rate of the transformed cells was the same as that of the control cells in culture. These results indicate that the cell growth potential in vitro is irrelevant to metastatic potential of the cells in vivo.
据报道，nm23/核苷二磷酸激酶（NDP激酶）表达增加与乳腺癌转移潜能降低以及结肠腺癌和肺腺癌的肿瘤进展均相关。我们检测了nm23-R2大鼠NDP激酶α亚型的表达对小鼠腺癌细胞（结肠26细胞系）的影响，发现随着c-myc的过表达，转移潜能显著降低。我们还发现，转化细胞在培养中的增殖速率与对照细胞相同。这些结果表明，细胞的体外生长潜能与体内细胞的转移潜能无关。
