Eggleton P, Reid K B, Tenner A J
Dept of Biochemistry, University of Oxford, UK.
Trends Cell Biol. 1998 Nov;8(11):428-31. doi: 10.1016/s0962-8924(98)01373-7.
C1, the first component of the classical pathway of complement activation is a complex of three proteins called C1q, C1r and C1s. Normally, C1q binding to aggregated IgG molecules results in activation of the classical pathway of complement. However, C1q has a number of other observed functions, not directly related to complement, that could be mediated by recently identified binding proteins acting as cell-surface receptors or soluble modulators of C1q-mediated functions. This article discusses the various activities of C1q and the evidence that these functions might be influenced by both membrane-bound and soluble C1q-binding proteins.
C1是补体激活经典途径的首个成分，是一种由C1q、C1r和C1s三种蛋白质组成的复合物。正常情况下，C1q与聚集的IgG分子结合会导致补体经典途径的激活。然而，C1q还有许多其他已观察到的功能，这些功能与补体并无直接关联，可能由最近鉴定出的作为细胞表面受体或C1q介导功能的可溶性调节剂的结合蛋白介导。本文讨论了C1q的各种活性，以及这些功能可能受到膜结合型和可溶性C1q结合蛋白影响的证据。
