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大鼠甲状腺中甲状腺过氧化物酶的定位及碘化位点

Localization of thyroid peroxidase and the site of iodination in rat thyroid gland.

作者信息

Edwards H H, Morrison M

出版信息

Biochem J. 1976 Aug 15;158(2):477-9. doi: 10.1042/bj1580477.

DOI:10.1042/bj1580477
PMID:985439
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1163991/
Abstract

The iodinated protein was localized in thyroid tissue slices by using radioautography. In unfixed tissue, the labelled protein was localized in the colloid, whereas, in tissue that was fixed before the 125I addition, the label was within the follicular cell. This localizes thyroid peroxidase largely on the endoplasmic reticulum of the cell.

摘要

通过放射自显影法将碘化蛋白定位在甲状腺组织切片中。在未固定的组织中，标记蛋白定位于胶体中，而在添加¹²⁵I之前固定的组织中，标记物位于滤泡细胞内。这表明甲状腺过氧化物酶主要定位于细胞的内质网上。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35c3/1163991/1fe44b14cdd7/biochemj00527-0322-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35c3/1163991/1fe44b14cdd7/biochemj00527-0322-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35c3/1163991/1fe44b14cdd7/biochemj00527-0322-a.jpg

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本文引用的文献

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AN ELECTRON MICROSCOPIC STUDY OF THE SITE OF IODINE BINDING IN THE RAT THYROID GLAND.大鼠甲状腺中碘结合位点的电子显微镜研究。
Exp Cell Res. 1965 Apr;38:50-6. doi: 10.1016/0014-4827(65)90426-x.
2
NATURE OF THE PORPHYRIN GROUP OF A HEME PROTEIN FRACTION ISOLATED FROM MAMMALIAN THYROID MICROSOMES.从哺乳动物甲状腺微粒体中分离出的血红素蛋白组分的卟啉基团的性质
Endocrinology. 1965 Mar;76:555-8. doi: 10.1210/endo-76-3-555.
3
METABOLISM OF 125-I IN THE THYROID GLAND STUDIES WITH ELECTRON MICROSCOPIC AUTORADIOGRAPHY.用电子显微镜放射自显影术研究甲状腺中125碘的代谢
丙硫氧嘧啶处理大鼠甲状腺滤泡细胞中过氧化物酶和产过氧化氢的NAD(P)H氧化酶的细胞化学定位
Histochemistry. 1985;82(3):263-8. doi: 10.1007/BF00501403.
4
Subcellular structure of bovine thyroid gland. The localization of the peroxidase activity in bovine thyroid.牛甲状腺的亚细胞结构。牛甲状腺中过氧化物酶活性的定位。
Biochem J. 1978 Sep 15;174(3):939-49. doi: 10.1042/bj1740939.
Endocrinology. 1964 Nov;75:787-98. doi: 10.1210/endo-75-5-787.
4
Localization of protein-bound I131 in the thyroid gland of the mouse.蛋白质结合的碘-131在小鼠甲状腺中的定位。
Endocrinology. 1955 Jan;56(1):9-20. doi: 10.1210/endo-56-1-9.
5
Purification and iodinating activity of hog thyroid peroxidase.猪甲状腺过氧化物酶的纯化及碘化活性
J Biol Chem. 1967 Dec 10;242(23):5510-23.
6
Studies on the biosynthesis of thyroid hormone: bulk fractionation procedures and absorbency spectra of calf thyroid, iodide peroxidase-tyrosine iodinase; stabilization of enzyme and polymeric structure.
Endocrinology. 1971 Feb;88(2):470-85. doi: 10.1210/endo-88-2-470.
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Fine structural localization of peroxidase in the rat thyroid.大鼠甲状腺中过氧化物酶的精细结构定位
Z Zellforsch Mikrosk Anat. 1970;107(1):104-10. doi: 10.1007/BF00338961.
8
Protein composition of the colloid collected from single rat thyroid follicles.从单个大鼠甲状腺滤泡收集的胶体的蛋白质组成。
Biochem Biophys Res Commun. 1970 Mar 27;38(6):1168-73. doi: 10.1016/0006-291x(70)90362-1.
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Ultrastructural localization of peroxidase activity on some membranes of the typical thyroid epithelial cell.典型甲状腺上皮细胞某些膜上过氧化物酶活性的超微结构定位。
Lab Invest. 1972 Jan;26(1):63-73.
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