血小板形态改变过程中可被神经氨酸酶去除的唾液酸增加。
Increase in sialic acids removable by neuraminidase during the shape change of platelets.
作者信息
Motamed M, Michal F, Born G V
出版信息
Biochem J. 1976 Sep 15;158(3):655-7. doi: 10.1042/bj1580655.
Abstract
Human or rabbit platelets were activated by ADP or 5-hydroxytrypatamine and rapidly fixed with glutaraldehyde. The shape change associated with activation gave rise to an increase in sialic acids removable by neuraminidase. This increase, like the shape change, was prevented by adenosine or methysergide added before ADP or 5-hydroxytryptamine respectively. The results indicate the exposure of additional glycoprotein(s) on the platelet surface.
摘要
人或兔血小板被二磷酸腺苷（ADP）或5-羟色胺激活，然后迅速用戊二醛固定。与激活相关的形状变化导致神经氨酸酶可去除的唾液酸增加。这种增加，与形状变化一样，分别在添加ADP或5-羟色胺之前加入腺苷或甲基麦角新碱可被阻止。结果表明血小板表面有额外的糖蛋白暴露。
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