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多房棘球绦虫的嘌呤代谢

Purine metabolism in Echinococcus multilocularis.

作者信息

Suchail S, Sarciron M E, Petavy A F

机构信息

Department of Parasitology and Medical Mycology, Claude-Bernard University, Lyon, France.

出版信息

Comp Biochem Physiol B Biochem Mol Biol. 1998 Aug;120(4):633-7. doi: 10.1016/s0305-0491(98)10054-8.

Abstract

The activities of the enzymes in Echinococcus multilocularis metacestodes involved in purine salvage were studied by HPLC. As in most parasites, this cestode relies entirely on salvage of preformed bases and nucleosides for its purine requirement. Therefore, these enzymes may be targets for drugs in the chemotherapeutic treatment of diseases caused by this parasite. The animals used in this study were gerbils (Meriones unguiculatus). Enzyme activities from sera and hepatic tissue in control and infected animals were similar with the exception of adenine phosphoribosyltransferase which showed an activity 4-fold greater in the serum from control than in serum from infected animals. In the parasite, adenine and hypoxanthine-guanine phosphoribosyltransferases and adenosine deaminase had the highest activities. Therefore, in E. multilocularis metacestodes, this pathway seems to be important for the parasite's metabolism.

摘要

通过高效液相色谱法(HPLC)研究了多房棘球绦虫幼虫中参与嘌呤补救途径的酶的活性。与大多数寄生虫一样,这种绦虫完全依赖于现成的碱基和核苷的补救来满足其嘌呤需求。因此,这些酶可能是用于治疗由这种寄生虫引起的疾病的化疗药物的靶点。本研究中使用的动物是沙鼠(长爪沙鼠)。对照动物和感染动物血清及肝组织中的酶活性相似,但腺嘌呤磷酸核糖转移酶除外,其在对照动物血清中的活性比感染动物血清中的活性高4倍。在寄生虫中,腺嘌呤和次黄嘌呤-鸟嘌呤磷酸核糖转移酶以及腺苷脱氨酶具有最高的活性。因此,在多房棘球绦虫幼虫中,这条途径似乎对寄生虫的代谢很重要。

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