镰状细胞危象期间白细胞介素-8水平升高。
Elevated IL-8 levels during sickle cell crisis.
作者信息
Duits A J, Schnog J B, Lard L R, Saleh A W, Rojer R A
机构信息
Department of Internal Medicine, and Red Cross Bloodbank Curaçao, St Elizabeth Hospital Curaçao, Netherlands Antilles. aduits@ibmnet
出版信息
Eur J Haematol. 1998 Nov;61(5):302-5. doi: 10.1111/j.1600-0609.1998.tb01092.x.
The vaso-occlusive process (VOC) in sickle cell disease is of a complex nature. It involves intricate interactions between sickle red blood cells, endothelium and probably also leukocytes. As these interactions are regulated by cytokines, we analyzed the role of the potent neutrophil chemokine IL-8 by measuring serum levels in sickle cell patients during sickle cell crisis. These results were compared to nonsymptomatics and healthy controls. In patients having a vaso-occlusive crisis both HbSS and HbSC patients showed significantly enhanced serum IL-8 levels compared to healthy controls. Several of these patients showed extremely elevated serum IL-8 levels which were independent of the crisis inducing factor. Furthermore, a sickle cell patient with VOC as a complication of rhGM-CSF treatment similarly showed high IL-8 serum levels at crisis onset. Nonsymptomatic sickle cell patients serum IL-8 levels were comparable to healthy controls. These results implicate a role for IL-8 at or during (the initiation of) sickle cell crisis.
镰状细胞病中的血管阻塞过程（VOC）性质复杂。它涉及镰状红细胞、内皮细胞以及可能还有白细胞之间的复杂相互作用。由于这些相互作用受细胞因子调节，我们通过测量镰状细胞病患者在镰状细胞危象期间的血清水平，分析了强效中性粒细胞趋化因子白细胞介素-8（IL-8）的作用。将这些结果与无症状患者和健康对照进行比较。在发生血管阻塞危象的患者中，与健康对照相比，血红蛋白SS（HbSS）和血红蛋白SC（HbSC）患者的血清IL-8水平均显著升高。其中一些患者的血清IL-8水平极高，且与危象诱发因素无关。此外，一名因重组人粒细胞巨噬细胞集落刺激因子（rhGM-CSF）治疗并发VOC的镰状细胞病患者在危象发作时同样显示出高血清IL-8水平。无症状镰状细胞病患者的血清IL-8水平与健康对照相当。这些结果表明IL-8在镰状细胞危象发生时或期间起作用。
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