Shields S A, Gregor K J, Young C H, James S P
Outcomes Research, PCS Health Systems, Inc., Scottsdale, Arizona, USA.
Pharmacotherapy. 1998 Nov-Dec;18(6):1298-303.
We conducted a retrospective analysis to evaluate the relationship between anxiolytic or hypnotic therapy and maintenance of therapy with selective serotonin reuptake inhibitors (SSRIs). Subjects were 654 patients who received anxiolytics or hypnotics early in SSRI therapy (study group ) and 15,172 patients who did not (controls). Maintenance of SSRI therapy was evaluated during the 6 months after start of therapy and included days of initial SSRI therapy and rates of discontinuation, defined as a break of more than 30 days. Rates of discontinuation in study and control groups (84% and 77%, p=0.001) and average days of initial SSRI therapy (77 and 94 days, p<0.0001) were statistically different. Thus patients receiving anxiolytic or hypnotics in the first 60 days of therapy were less likely to continue initial SSRI therapy.
我们进行了一项回顾性分析，以评估抗焦虑或催眠治疗与选择性5-羟色胺再摄取抑制剂（SSRI）维持治疗之间的关系。研究对象为654例在SSRI治疗早期接受抗焦虑或催眠药物治疗的患者（研究组）和15172例未接受此类治疗的患者（对照组）。在开始治疗后的6个月内评估SSRI治疗的维持情况，包括初始SSRI治疗的天数和停药率，停药定义为中断超过30天。研究组和对照组的停药率（分别为84%和77%，p=0.001）以及初始SSRI治疗的平均天数（分别为77天和94天，p<0.0001）存在统计学差异。因此，在治疗的前60天接受抗焦虑或催眠药物治疗的患者继续初始SSRI治疗的可能性较小。
