环磷酰胺脉冲疗法治疗慢性炎症性脱髓鞘性多发性神经病
Pulse cyclophosphamide therapy in chronic inflammatory demyelinating polyneuropathy.
作者信息
Good J L, Chehrenama M, Mayer R F, Koski C L
机构信息
University of Maryland School of Medicine, Department of Neurology, Baltimore 21201, USA.
出版信息
Neurology. 1998 Dec;51(6):1735-8. doi: 10.1212/wnl.51.6.1735.
PMID:9855536
Abstract
Fifteen patients with chronic inflammatory demyelinating neuropathy (CIDP) were treated with pulse intravenous cyclophosphamide (IVCY) monthly for up to 6 months. Eleven patients reached a complete remission; only one patient worsened. Complications included nausea, vomiting, anemia, and hair loss. This case series suggests that monthly IVCY is beneficial in the treatment of CIDP and warrants a controlled study.
摘要
15例慢性炎症性脱髓鞘性多发性神经病（CIDP）患者每月接受静脉注射环磷酰胺（IVCY）冲击治疗，持续6个月。11例患者完全缓解，仅1例患者病情恶化。并发症包括恶心、呕吐、贫血和脱发。该病例系列表明，每月一次的IVCY治疗对CIDP有效，值得进行对照研究。
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