Kawano Y, Yoshimi H, Matsuoka H, Takishita S, Omae T
Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Osaka, Japan.
J Hypertens. 1998 Nov;16(11):1693-9. doi: 10.1097/00004872-199816110-00017.
To study the effects of a high calcium intake in hypertensive patients by blood pressure monitoring.
In a randomized crossover study, patients were assigned to an 8-week calcium supplementation period and an 8-week control period. The subjects were given 25 mmol/day (1 g/day) of calcium as calcium carbonate during the intervention period.
A hypertension clinic in a tertiary teaching hospital.
Sixty untreated or treated hypertensive patients (35 men and 25 women, mean age 58 years) with office systolic/diastolic blood pressure > or = 140/90 mmHg.
Office blood pressure, home blood pressure (last 7 days), and ambulatory 24 h blood pressure (every 30 min using TM-2421).
The serum calcium concentration and urinary calcium excretion increased significantly with calcium supplementation. Office, home and 24 h blood pressure were lower in the calcium period than in the control period, although the differences were small (mean +/- SEM office blood pressure: 1.2+/-1.2/1.1+/-0.7 mmHg; home blood pressure: 1.9+/-0.7/1.3+/-0.6 mmHg; 24 h blood pressure: 1.2+/-0.8/0.9+/-0.5 mmHg,), and significant only for home systolic and diastolic blood pressures. The difference in home systolic blood pressure was inversely correlated with the level of home blood pressure in the control period and with the difference in urinary calcium. The difference in 24 h systolic blood pressure was positively correlated with the control level of urinary calcium. Age, sex, antihypertensive medication, drinking habit, sodium intake or order of treatment did not significantly influence the effects of calcium supplementation.
An increase in calcium intake tends to lower office, home and ambulatory blood pressure in hypertensive patients. However, the antihypertensive effect is too small to support the general application of a high calcium intake in the treatment of hypertension.
通过血压监测研究高钙摄入量对高血压患者的影响。
在一项随机交叉研究中，患者被分配到为期8周的补钙期和为期8周的对照期。在干预期，受试者每天服用25毫摩尔（1克）碳酸钙形式的钙。
一家三级教学医院的高血压诊所。
60名未治疗或正在治疗的高血压患者（35名男性和25名女性，平均年龄58岁），诊室收缩压/舒张压≥140/90毫米汞柱。
诊室血压、家庭血压（最近7天）和动态24小时血压（使用TM - 2421每30分钟测量一次）。
补钙后血清钙浓度和尿钙排泄量显著增加。补钙期的诊室、家庭和24小时血压均低于对照期，尽管差异较小（平均±标准误，诊室血压：1.2±1.2/1.1±0.7毫米汞柱；家庭血压：1.9±0.7/1.3±0.6毫米汞柱；24小时血压：1.2±0.8/0.9±0.5毫米汞柱），且仅家庭收缩压和舒张压有显著差异。家庭收缩压的差异与对照期家庭血压水平及尿钙差异呈负相关。24小时收缩压的差异与尿钙对照水平呈正相关。年龄、性别、抗高血压药物、饮酒习惯、钠摄入量或治疗顺序均未显著影响补钙效果。
钙摄入量增加往往会降低高血压患者的诊室、家庭和动态血压。然而，降压效果过小，不足以支持在高血压治疗中普遍应用高钙摄入量。
