Nakamura T, Ebihara I, Shimada N, Shoji H, Koide H
Department of Medicine, Misato Junshin Hospital, Saitama, Tokyo, Japan.
Am J Med Sci. 1998 Dec;316(6):355-60. doi: 10.1097/00000441-199812000-00001.
The authors measured plasma metalloproteinase (MMP)-9 and corresponding monocyte mRNA in 20 patients with septic shock. Plasma MMP-9 concentrations and monocyte MMP-9 mRNA levels were significantly higher in the 10 nonsurviving patients with septic shock than in 10 surviving patients and 25 normal controls. Hemoperfusion using polymyxin B immobilized on fibers (PMX-F), a reportedly effective treatment for septic shock, was studied for effects on MMP-9 in the patients. Increases in plasma MMP-9 concentrations and corresponding monocyte mRNA levels were attenuated significantly by PMX-F treatment in both nonsurviving and surviving patients. These data suggest that plasma MMP-9 concentrations and monocyte MMP-9 mRNA levels may be useful prognostic markers in septic shock, and that PMX-F treatment affects MMP-9.
作者检测了20例感染性休克患者的血浆金属蛋白酶（MMP）-9及相应的单核细胞mRNA。10例感染性休克死亡患者的血浆MMP-9浓度和单核细胞MMP-9 mRNA水平显著高于10例存活患者及25例正常对照。对使用固定在纤维上的多黏菌素B（PMX-F）进行血液灌流（一种据报道对感染性休克有效的治疗方法）治疗患者时MMP-9的影响进行了研究。在死亡和存活患者中，PMX-F治疗均显著减弱了血浆MMP-9浓度及相应单核细胞mRNA水平的升高。这些数据表明，血浆MMP-9浓度和单核细胞MMP-9 mRNA水平可能是感染性休克有用的预后标志物，且PMX-F治疗会影响MMP-9。
