Wülfing C, Davis M M
Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Science. 1998 Dec 18;282(5397):2266-9. doi: 10.1126/science.282.5397.2266.
During T cell activation, the engagement of costimulatory molecules is often crucial to the development of an effective immune response, but the mechanism by which this is achieved is not known. Here, it is shown that beads attached to the surface of a T cell translocate toward the interface shortly after the start of T cell activation. This movement appears to depend on myosin motor proteins and requires the engagement of the major costimulatory receptor pairs, B7-CD28 and ICAM-1-LFA-1. This suggests that the engagement of costimulatory receptors triggers an active accumulation of molecules at the interface of the T cell and the antigen-presenting cell, which then increases the overall amplitude and duration of T cell signaling.
在T细胞活化过程中，共刺激分子的结合对于有效免疫反应的发展通常至关重要，但其实现机制尚不清楚。在此研究中，结果表明附着于T细胞表面的珠子在T细胞活化开始后不久便向界面移动。这种移动似乎依赖于肌球蛋白运动蛋白，并且需要主要共刺激受体对B7 - CD28和ICAM - 1 - LFA - 1的结合。这表明共刺激受体的结合触发了分子在T细胞与抗原呈递细胞界面处的主动积累，进而增加了T细胞信号传导的总体幅度和持续时间。
