Suppr超能文献

[水平喉切除术治疗喉癌——肿瘤学及功能结果]

[Horizontal laryngectomy in treatment of laryngeal cancer--oncologic and function results].

作者信息

Jaworowska E

机构信息

Kliniki Otolaryngologii Pomorskiej Akademii Medycznej w Szczecinie.

出版信息

Ann Acad Med Stetin. 1998;44:175-95.

PMID:9857538
Abstract

The purpose of this paper was the retrospective evaluation of the results after horizontal partial larynx resection of different dimension. The material comprised 468 patients treated according to the described techniques in ENT Clinic Pom. Med. Acad. between 1970-1991. The series of patients subjected to analysis consisted of 35% of all cases treated by surgery and 70% of all conservative operations performed for cancer of the larynx in the above-mentioned period of time. Particulars were obtained from: a) case history, b) control examination, c) correspondence, d) data from USC. The results of the treatment in particular groups were submitted for detailed analysis. The assessment of applied technique from oncologic point of view was done on the basis of local recurrences and percentage of 3 and 5 years survival rate. Functional results were evaluated according to protective, respiratory and phonatory functions of the residual larynx. Results of the investigations were submitted for statistic valuation. In all types of operations satisfactory oncologic results were achieved. They were represented by high percentage of survival rate and low percentage of local recurrences. The longest survival 3- and 5-years respectively (73.90%) and 63.45%) and the lowest index of local failure (4.2%) were seen after classic, supraglottic resection. After horizontal glottic larynx resection 8/10 of patients operated on survived 3 years, 4/6 survived 5 years. Local recurrence was observed in 1/12 patients (Tab. 2). The lowest rate of survival (54.76% and 42.86%) and the highest number of local failures (11.3%) were revented after supracricoid laryngectomy with cricohyoidoepiglottopexy (CHEP)--in this group carcinomas staged T3 were predominant. After enlarged supraglottic laryngectomy and supracricoid resection with cricohyoidopexy (CHP) oncologic results were very close (Fig. 1). No substantial statistical difference was recorded in survival percentage after enlarged supraglottic larynx resection (70.51% and 61.66%) and supracricoid one with CHP (68.54% and 58.43%), nor in percentage of local recurrences (4.4% and 5.7%). The efficiency of the residual larynx was dependent on the extent of the resection. From the discussed types of operations the best functional results were achieved after classic supraglottic and glottic larynx resections. This was distinct in the best quality of speech, efficient respiratory tract protection and high percentage of decannulated cases (93%). In the glottic resection the respiratory tract protection was satisfactory in 9/11 patients and in 7/8 satisfactory speech quality was noticed. Following the extended laryngeal structures resection (extended supraglotic and supracricoid laryngectomies) worse protection of respiratory tract, higher percentage of not decannulated cases and worse quality of speech were observed than in operation previously discussed. It was proved that the one-stage reconstruction of the laryngeal structures (arytenoid cartilage and/or vocal cord) or base of the tongue improves the result considerably, in particular the deglutition and phonation. The oncologic and functional results after the discussed types of operation should stimulate their more frequent application in larynx cancer treatment.

摘要

本文旨在对不同范围水平部分喉切除术的结果进行回顾性评估。研究材料包括1970年至1991年间在波美拉尼亚医科大学耳鼻喉科诊所按照所述技术治疗的468例患者。接受分析的患者系列占同期所有接受手术治疗病例的35%,以及所有针对喉癌进行的保守手术的70%。具体信息来自:a)病历,b)对照检查,c)通信,d)美国国立医学图书馆的数据。对特定组别的治疗结果进行了详细分析。从肿瘤学角度对所应用技术的评估基于局部复发情况以及3年和5年生存率百分比。根据残余喉部的保护、呼吸和发声功能评估功能结果。研究结果进行了统计学评估。在所有类型的手术中均取得了令人满意的肿瘤学结果。表现为高生存率百分比和低局部复发百分比。经典声门上切除术之后分别观察到最长的3年(73.90%)和5年(63.45%)生存率以及最低的局部失败指数(4.2%)。水平声门型喉切除术后接受手术的患者中有8/10存活3年,4/6存活5年。1/12的患者观察到局部复发(表2)。环状软骨上喉切除术加环状软骨舌骨会厌固定术(CHEP)之后观察到最低的生存率(54.76%和42.86%)以及最高的局部失败率(11.3%)——该组中T3期癌占主导。扩大声门上喉切除术和环状软骨上切除术加环状软骨舌骨固定术(CHP)之后的肿瘤学结果非常接近(图1)。扩大声门上喉切除术(70.51%和61.66%)和环状软骨上切除术加CHP(68.54%和58.43%)后的生存率百分比以及局部复发百分比(4.4%和5.7%)均未记录到实质性统计学差异。残余喉部的效能取决于切除范围。在所讨论的手术类型中,经典声门上型和声门型喉切除术后取得了最佳的功能结果。这在最佳的语音质量、有效的呼吸道保护以及高拔管率(93%)方面表现明显。在声门切除术中,9/11的患者呼吸道保护令人满意,7/8的患者语音质量令人满意。与先前讨论的手术相比,在扩大喉部结构切除术后(扩大声门上型和环状软骨上型喉切除术)观察到呼吸道保护较差、未拔管病例百分比更高以及语音质量更差。事实证明,喉部结构(杓状软骨和/或声带)或舌根的一期重建可显著改善结果,尤其是吞咽和发声功能。所讨论的手术类型后的肿瘤学和功能结果应促使其在喉癌治疗中更频繁地应用。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验