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[过敏性肺泡炎和结节病患者支气管肺泡灌洗中的Ⅲ型前胶原]

[Procollagen III in bronchoalveolar lavage fluid of patients with allergic alveolitis and sarcoidosis].

作者信息

Jastrzebski D, Ziora D, Oklek K

机构信息

Katedry i Kliniki Ftizjopneumonologii Sl. A. M. w Zabrzu.

出版信息

Pneumonol Alergol Pol. 1998;66(5-6):312-20.

PMID:9857652
Abstract

In 12 patients with sarcoidosis and 11 patients with allergic alveolitis concentration of procollagen III peptide in bronchoalveolar lavage fluid (in bronchial and alveolar fraction) was estimated using RIA method. In studied populations procollagen III levels were higher in comparison to control. In patients with allergic alveolitis and with DLCO < 60% pred. procollagen III peptide concentrations in BAL fluid were significantly higher than in patients with sarcoidosis. In patients with allergic alveolitis a positive correlation between BAL lymphocytes number and procollagen III peptide concentration was observed.

摘要

采用放射免疫分析法(RIA)对12例结节病患者和11例过敏性肺泡炎患者支气管肺泡灌洗液(支气管和肺泡部分)中Ⅲ型前胶原肽的浓度进行了测定。在所研究的人群中,Ⅲ型前胶原水平高于对照组。在过敏性肺泡炎且肺一氧化碳弥散量(DLCO)<预测值60%的患者中,支气管肺泡灌洗液中Ⅲ型前胶原肽浓度显著高于结节病患者。在过敏性肺泡炎患者中,观察到支气管肺泡灌洗淋巴细胞数量与Ⅲ型前胶原肽浓度之间呈正相关。

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Pneumonol Alergol Pol. 1998;66(5-6):312-20.
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