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[1991年至1996年华沙医学院肺病诊所急性哮喘中心治疗的哮喘持续状态患者死亡情况分析]

[Analysis of deaths during the course of status asthmaticus in patients treated at the Acute Asthma Center in the Pneumonology Clinic of the Warsaw Medical School in the years 1991-1996].

作者信息

Karwat K, Droszcz P

机构信息

Katedry i Kliniki Chorób Wewnetrznych i Pneumonologii AM w Warszawie.

出版信息

Pneumonol Alergol Pol. 1998;66(3-4):141-7.

PMID:9857657
Abstract

In the Acute Asthma Treatment Center (OLSA) in the Department of Pneumonology of Warsaw Medical School in years 1991-1996, 582 patients with status asthmaticus were treated. The causes of status asthmaticus were bronchial asthma in 317 patients and COPD in 265 patients. Status asthmaticus was the cause of death in 21 patients treated in OLSA, which accounts for 3.6% of the total. 10 subjects were admitted with symptoms of brain death, who underwent resuscitation on their way to hospital. This study retrospectively analyzes the clinical characteristics (age, sex, PaCO2, pH, PaO2, time of mechanical ventilation and duration of treatment in ICU) of patients who died in status asthmaticus. They were divided into two groups: patients with asthma and COPD. A significant difference (p < 0.01) was detected between those two groups only in patients age. Mean duration of mechanical ventilation was 151 h in asthmatic and 104 h in COPD group. Mean duration of the OLSA stay was 19.5 days in the first and 7.4 days in the second group. The following fatal complications were observed: 2 cerebral strokes, 4 cardiac infarctions, 3 pneumothoraces, 2 atelectasis, 4 pneumonia, 1 case of gastric hemorrhage and 1 hemorrhage to mediastinum.

摘要

1991年至1996年期间,华沙医学院肺病学系急性哮喘治疗中心(OLSA)收治了582例哮喘持续状态患者。哮喘持续状态的病因中,317例为支气管哮喘,265例为慢性阻塞性肺疾病(COPD)。在OLSA接受治疗的患者中,有21例因哮喘持续状态死亡,占总数的3.6%。10名患者入院时伴有脑死亡症状,在送往医院途中接受了复苏治疗。本研究回顾性分析了死于哮喘持续状态患者的临床特征(年龄、性别、动脉血二氧化碳分压、pH值、动脉血氧分压、机械通气时间和重症监护病房治疗时间)。他们被分为两组:哮喘患者和COPD患者。两组之间仅在患者年龄方面存在显著差异(p < 0.01)。哮喘组机械通气的平均时间为151小时,COPD组为104小时。第一组在OLSA的平均住院时间为19.5天,第二组为7.4天。观察到以下致命并发症:2例脑卒 中、4例心肌梗死、3例气胸、2例肺不张、4例肺炎、1例胃出血和1例纵隔出血。

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