Olas B, Wachowicz B
Katedra Biochemii Ogólnej Uniwersytetu Lódzkiego, Lodzi.
Postepy Hig Med Dosw. 1998;52(5):471-87.
Thrombin is a serine protease that plays a central role in hemostatic and thrombotic events. The structure, different forms of thrombin, its role in platelet activation and in other cellular effects are reviewed. Two distinct receptors involved in platelet activation induced by alpha-thrombin are presented: a high affinity (GPIb) coupled to phospholipase A2 and a moderate affinity, G protein associated with seven transmembrane domain receptor (STDR) coupled to phospholipase C.
凝血酶是一种丝氨酸蛋白酶，在止血和血栓形成过程中起核心作用。本文综述了凝血酶的结构、不同形式、其在血小板激活及其他细胞效应中的作用。文中介绍了两种与α-凝血酶诱导的血小板激活相关的不同受体：一种是与磷脂酶A2偶联的高亲和力受体（糖蛋白Ib），另一种是与磷脂酶C偶联的中等亲和力的、与七跨膜结构域受体（STDR）相关的G蛋白。
