Asadullah K, Döcke W D, Volk H D, Sterry W
Department of Dermatology, Medical School Charité, Humboldt-University Berlin, Germany.
Exp Dermatol. 1998 Dec;7(6):314-20. doi: 10.1111/j.1600-0625.1998.tb00330.x.
Cytokines are considered to be of major importance for the pathogenesis of cutaneous T-cell lymphomas (CTCL). Their impact may result from autocrine, paracrine or endocrine effects. Several investigations demonstrated the overexpression of different cytokines in different CTCL entities. Interestingly, stage-dependent shifts in the cytokine pattern have been observed in mycosis fungoides (MF). There is evidence that the abnormal cytokine expression in CTCL might be responsible for tumor progression, resulting from an enhanced proliferation of the malignant cells and/or the depression of the anti-tumor immune response. Moreover, cytokine loops might explain phenomena like the epidermotropism of malignant cells or eosinophilia and increased plasma levels of IgE, which are present in advanced stages of CTCL. Analysis of the cytokine pattern in CTCL might give the basis for direct therapeutic intervention into the cytokine network as a new therapeutic approach. In this review, the current knowledge regarding cytokines in CTCL is summarized.
细胞因子被认为在皮肤T细胞淋巴瘤（CTCL）的发病机制中起主要作用。它们的影响可能源于自分泌、旁分泌或内分泌效应。多项研究表明，不同细胞因子在不同CTCL实体中存在过表达。有趣的是，在蕈样肉芽肿（MF）中观察到细胞因子模式的分期依赖性变化。有证据表明，CTCL中异常的细胞因子表达可能导致肿瘤进展，这是由于恶性细胞增殖增强和/或抗肿瘤免疫反应受到抑制所致。此外，细胞因子循环可能解释恶性细胞向表皮游走、嗜酸性粒细胞增多以及CTCL晚期出现的IgE血浆水平升高等现象。分析CTCL中的细胞因子模式可能为直接干预细胞因子网络提供依据，从而成为一种新的治疗方法。在这篇综述中，总结了目前关于CTCL中细胞因子的知识。
