Ferland R J, Applegate C D
Program in Neuroscience, The Strong Epilepsy Center, University of Rochester School of Medicine and Dentistry, NY 14642, USA.
Neuroreport. 1998 Nov 16;9(16):3623-9. doi: 10.1097/00001756-199811160-00013.
Flurothyl kindling initiates a time-dependent process that results in a facilitated propagation from the forebrain to the brainstem seizure system and in an increase in the complexity of behavioral seizure expression. We investigated the involvement of the ventromedial nucleus of the hypothalamus (VMH) in mediating this facilitated propagation between these seizure systems. Bilateral ibotenic acid lesions of the VMH, but not the dorsomedial nucleus of the hypothalamus (DMH), resulted in a disruption in the propagation of seizure activity from the forebrain to the brainstem. Moreover, VMH lesioned mice were able to express brainstem seizures following minimal corneal electroconvulsive shock (mECS). Together, our results indicate that the VMH is a critical substrate involved in propagating seizure activity between the forebrain and brainstem, but is not involved in the expression systems necessary for forebrain or brainstem seizure manifestations.
氟乙酰胺点燃引发了一个时间依赖性过程，该过程导致癫痫活动从前脑到脑干癫痫发作系统的传播变得更容易，并且行为性癫痫发作表现的复杂性增加。我们研究了下丘脑腹内侧核（VMH）在介导这些癫痫发作系统之间这种促进性传播中的作用。VMH的双侧鹅膏蕈氨酸损伤，而非下丘脑背内侧核（DMH）的损伤，导致癫痫活动从前脑到脑干的传播中断。此外，VMH损伤的小鼠在接受最小角膜电惊厥休克（mECS）后能够表现出脑干癫痫发作。总之，我们的结果表明，VMH是参与在前脑和脑干之间传播癫痫活动的关键底物，但不参与前脑或脑干癫痫发作表现所必需的表达系统。
