Ni J W, Takahashi M, Yatsugi S, Shimizu-Sasamata M, Yamaguchi T
Neuroscience Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co. Ltd., Tsukuba, Ibaraki, Japan.
Neuroreport. 1998 Nov 16;9(16):3719-24. doi: 10.1097/00001756-199811160-00027.
Middle cerebral artery (MCA) occlusion causes atrophy in the ipsilateral substantia nigra reticulata (SNR). The effects of glutamate AMPA receptor antagonism on SNR atrophy, which is supposed to inhibit excitatory inputs from the subthalamic nucleus to the SNR, was investigated in rats with permanent MCA occlusions. Histological examination revealed marked atrophy two weeks after MCA occlusion in the saline-treated control group. However, constant i.v. infusion of YM872, a selective AMPA receptor antagonist, for 2 weeks significantly reduced SNR atrophy; neurological deficits also decreased. These results suggest that the AMPA receptor may be involved in the pathogenesis of SNR atrophy during the subacute phase of focal cerebral ischemia.
大脑中动脉（MCA）闭塞会导致同侧黑质网状部（SNR）萎缩。在永久性MCA闭塞的大鼠中，研究了谷氨酸AMPA受体拮抗作用对SNR萎缩的影响，该拮抗作用被认为可抑制从丘脑底核到SNR的兴奋性输入。组织学检查显示，在生理盐水处理的对照组中，MCA闭塞两周后出现明显萎缩。然而，连续两周静脉内持续输注选择性AMPA受体拮抗剂YM872可显著减轻SNR萎缩；神经功能缺损也有所减少。这些结果表明，AMPA受体可能参与局灶性脑缺血亚急性期SNR萎缩的发病机制。
