Giuliano P, Marino R, Pinto M R, De Santis R
Laboratory of Cell Biology, Stazione Zoologica 'A. Dohrn', Villa Comunale, 80121, Naples, Italy.
Mech Dev. 1998 Nov;78(1-2):199-202. doi: 10.1016/s0925-4773(98)00143-9.
Here we describe the cloning and expression pattern of Ci-isl, a homologue of vertebrate genes, in the ascidian. Early in development, Ci-isl expression occurs in the primordia of palps and brain vesicle, then in the tailbud embryo it is transiently extended to the notochord cells. At larva stage, the expression is down-regulated in the notochord, and it persists predominantly in the compartments of the nervous system. These observations indicate that also in invertebrates, islet genes show an expression pattern during differentiation of the nervous system.
在此，我们描述了脊椎动物基因的同源物Ci-isl在海鞘中的克隆及表达模式。在发育早期，Ci-isl表达出现在触须和脑泡的原基中，然后在尾芽胚胎中，它短暂地扩展到脊索细胞。在幼虫阶段，脊索中的表达下调，并且它主要持续存在于神经系统的各个部分。这些观察结果表明，在无脊椎动物中，胰岛基因在神经系统分化过程中也呈现出一种表达模式。
