猪肾中嘧啶选择性钠/核苷共转运体pkCNT1的序列
Sequence of a pyrimidine-selective Na+/nucleoside cotransporter from pig kidney, pkCNT1.
作者信息
Pajor A M
机构信息
University of Arizona, Department of Physiology, College of Medicine, Tucson, AZ 85724-5051,
出版信息
Biochim Biophys Acta. 1998 Dec 9;1415(1):266-9. doi: 10.1016/s0005-2736(98)00192-8.
PMID:9858747
Abstract
A 3 kb cDNA called pkCNT1, a new member of the Na+/nucleoside cotransporter family, was cloned from pig kidney and sequenced. The sequence of pkCNT1 encodes a 647 amino acid protein that is 84% identical to the sequence of the rat pyrimidine-selective Na+/nucleoside cotransporter, rCNT1. pkCNT1 transports pyrimidines, such as thymidine and uridine, and has a Km for uridine of 9 microM.
摘要
一个名为pkCNT1的3 kb cDNA，它是Na+/核苷共转运体家族的新成员，从猪肾中克隆并测序。pkCNT1的序列编码一个647个氨基酸的蛋白质，该蛋白质与大鼠嘧啶选择性Na+/核苷共转运体rCNT1的序列有84%的同一性。pkCNT1转运嘧啶，如胸苷和尿苷，其对尿苷的Km值为9微摩尔。
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