Furukawa T, Yatsuoka T, Youssef E M, Abe T, Yokoyama T, Fukushige S, Soeda E, Hoshi M, Hayashi Y, Sunamura M, Kobari M, Horii A
Molecular Pathology, Tohoku University School of Medicine, Sendai; (Japan).
Cytogenet Cell Genet. 1998;82(3-4):156-9. doi: 10.1159/000015091.
DUSP6 (alias PYST1), one of the dual-specificity tyrosine phosphatases, is localized on 12q21, one of the regions of frequent allelic loss in pancreatic cancer. This gene is composed of three exons, and two forms of alternatively spliced transcripts are ubiquitously expressed. Although no mutations were observed in 26 pancreatic cancer cell lines, reduced expressions of the full-length transcripts were observed in some cell lines, which may suggest some role for DUSP6 in pancreatic carcinogenesis.
双特异性酪氨酸磷酸酶之一的DUSP6（别名PYST1）定位于12q21，这是胰腺癌中常见等位基因缺失区域之一。该基因由三个外显子组成，两种可变剪接转录本在全身广泛表达。虽然在26个胰腺癌细胞系中未观察到突变，但在一些细胞系中观察到全长转录本的表达降低，这可能表明DUSP6在胰腺癌发生过程中发挥了某种作用。
