Marín-Blázquez M D, Zuazu-Jausoro I, Rivera J, Sánchez I, Valdés M, Vicente V
Unidad de Oncohematología, Hospital General Universitario, Murcia.
Med Clin (Barc). 1998 Nov 7;111(15):578-9.
To evaluate haemostatic changes in coronary sinus (CS) and peripheral circulation (PC) in patients with cardiovascular disease (CAD) following PTCA.
We studied 12 patients scheduled for elective PTCA. Blood samples were obtained from CS and PC before angioplasty and after each balloon dilation. Expression of P selectin and several haemostatic parameters were determined.
D-Dimers (DD) plasma levels were significantly increased in samples from CS. No significant differences were found in other haemostatic parameters. A significant decrease of thrombin-antithrombin III levels after PTCA was assessed.
Intracoronary and peripheral hemostatic activation does not occur during and immediately following PTCA. No major differences in hemostatic parameters between CS and PC were observed in patients with CAD.
评估经皮冠状动脉腔内血管成形术（PTCA）后心血管疾病（CAD）患者冠状窦（CS）和外周循环（PC）中的止血变化。
我们研究了12例计划进行择期PTCA的患者。在血管成形术前以及每次球囊扩张后，从CS和PC采集血样。测定P选择素的表达和几个止血参数。
CS样本中的D - 二聚体（DD）血浆水平显著升高。在其他止血参数方面未发现显著差异。评估发现PTCA后凝血酶 - 抗凝血酶III水平显著降低。
PTCA期间及之后即刻未发生冠状动脉内和外周止血激活。在CAD患者中，未观察到CS和PC之间止血参数的重大差异。
