Braun J S, Apel I, Schäffer S, Schumacher M, Berger M
Abteilung für Psychiatrie und Psychotherapie, Albert-Ludwigs-Universität, Freiburg.
Nervenarzt. 1998 Nov;69(11):1015-8. doi: 10.1007/s001150050377.
In differential diagnosis of a delir also adverse effects of medicaments have to be taken into account beside other causes. We report a case of an agitated delir with nocturnal disturbance of consciousness, confusion, restlessness and sleeplessness. This delir existed exclusively during the therapy of a cutaneous herpes zoster with zovirax-pills which can only be explained by a causal connection--after exclusion of other causes. As a so far undescribed predisposition for neurotoxicity of oral therapy with acyclovir signs of vascular encephalopathy were found in the patient's cranial magnetic resonance imaging. The central nervous side effects of acyclovir were summarized shortly.
在谵妄的鉴别诊断中，除其他病因外，还必须考虑药物的不良反应。我们报告一例伴有夜间意识障碍、意识模糊、烦躁不安和失眠的激越性谵妄病例。这种谵妄仅在使用阿昔洛韦片治疗皮肤带状疱疹期间出现，排除其他病因后，只能用因果关系来解释。在患者的头颅磁共振成像中发现了血管性脑病的迹象，这是迄今为止未被描述的口服阿昔洛韦治疗产生神经毒性的易患因素。简要总结了阿昔洛韦的中枢神经副作用。
