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[产前心脏病学。从怀疑到确诊]

[Prenatal cardiology. Suspicion to confirmation].

作者信息

Macedo A J, Cruz C, Ribeiro H, Ferreira M, Kaku S

机构信息

Serviço de Cardiologia Pediátrica, Hospital de Santa Marta, Lisboa.

出版信息

Acta Med Port. 1998 Jul;11(7):655-8.

PMID:9859513
Abstract

The mortality rate is high and prognosis is worse among new-borns with prenatal diagnosis of heart malformation, mainly due to factors such as its association with other malformations, and a range of more severe diseases probably resulting from the predominance of the obstetric use of the four chamber view. In this study we retrospectively assessed the range of cardiopathies diagnosed by foetal echocardiography and their evolution, compared with previous years. From January 1994 to December 1995, 1173 foetal echocardiograms were performed at a gestation age of 24 weeks. Sixty-one foetuses (5.2%) had cardiac anomalies, structural in 56 and arrhythmia in 5. The risks and indications were maternal in 37%, foetal in 31%, familial in 17% and environmental in 15%. Three were false negatives (VSD:2; truncus arteriosus: 1). Five died in utero, and 18 were assessed after birth with a mean gestational age of 37 weeks and birth weight of 3 Kg, a caesarean section was performed in 9. All but one were born in central hospitals. Six children were operated on. Two children died, one after surgery. Compared with the four previous years of activity, indication due to foetal risk rose from 6 to 31%, the number of cases diagnosed with heart disease increased from 14 to 30 per year, and the mortality decreased from 59 to 11%. Despite this, we still observe that the vast majority of new-borns who are hospitalised due to a severe heart disease had no prenatal diagnosis, indicating the need to continue our educational policy in this field.

摘要

产前诊断为心脏畸形的新生儿死亡率高且预后较差,主要原因是其与其他畸形相关,以及一系列可能因产科四腔心切面检查占主导而导致的更严重疾病。在本研究中,我们回顾性评估了经胎儿超声心动图诊断的心脏病范围及其演变,并与前几年进行了比较。1994年1月至1995年12月,在孕24周时进行了1173次胎儿超声心动图检查。61例胎儿(5.2%)有心脏异常,其中56例为结构异常,5例为心律失常。风险和指征方面,母体因素占37%,胎儿因素占31%,家族因素占17%,环境因素占15%。有3例假阴性(室间隔缺损:2例;动脉干:1例)。5例在宫内死亡,18例出生后接受评估,平均胎龄37周,出生体重3千克,9例行剖宫产。除1例外均在中心医院出生。6名儿童接受了手术。2名儿童死亡,1名术后死亡。与此前四年的情况相比,因胎儿风险的指征从6%升至31%,每年诊断出的心脏病病例数从14例增至30例,死亡率从59%降至11%。尽管如此,我们仍观察到绝大多数因严重心脏病住院的新生儿未进行产前诊断,这表明有必要继续在该领域推行我们的教育政策。

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