Zlatkov V, Karag'ozov I
Akush Ginekol (Sofiia). 1998;37(2):57-9.
The aim of the present study was to examine the therapeutic possibilities of the wide-spectrum medicament Macmiror & Macmiror Complex for the treatment of the vaginal infections.
The study included 52 nonpregnant women among 20 u 54 years (middle age 30.5) with different by kind and intensity colpitis complains. The following microbiological characteristic was established: in 26 cases Candida spp., in 19 Gardnerella vaginalis, in 1 Trichomonas vaginalis and in the rest 6 mixed infection. The treatment of the patients was done in combined scheme: peroral and vaginal administration simultaneously with local treatment of the partner. The control examination was performed bistagely: on 7-10 day and on 30-40 day.
The good clinical and microbiological influence of the treated patients was established for the first control examination the effect was found in 89.5% u 84.2% go of the cases with bacterial vaginosis and in 84.6% u 69.2% in those with mycotic colpitis. Relatively high values were found also at the second control, respectively 83.3% and 72.2% for the amine colpitis and 69.5% and 52.2% for vaginal candidosis. The similar favorable influence received also in the rest of the patients.
Our results do show good possibilities of the nifuratel and nystatin combination (Macmiror & Macmiror complex) to influence vaginitis with different etiology, which give us founding to consider, that the drug is suitable for the mixed forms of vaginal infection.
本研究的目的是检验广谱药物麦米诺及麦米诺复方治疗阴道感染的可能性。
该研究纳入了52名年龄在20至54岁(平均年龄30.5岁)的非妊娠女性,她们患有不同类型和严重程度的阴道炎。确定了以下微生物学特征:26例为念珠菌属,19例为阴道加德纳菌,1例为阴道毛滴虫,其余6例为混合感染。患者采用联合方案治疗:口服和阴道给药同时对性伴侣进行局部治疗。对照检查分两个阶段进行:在第7至10天和第30至40天。
在首次对照检查中,确定治疗对患者有良好的临床和微生物学影响,细菌性阴道炎患者中89.5%至84.2%有效果,霉菌性阴道炎患者中84.6%至69.2%有效果。在第二次对照检查中也发现了相对较高的值,胺性阴道炎分别为83.3%和72.2%,阴道念珠菌病分别为69.5%和52.2%。其余患者也有类似的良好影响。
我们的结果确实表明硝呋太尔和制霉菌素组合(麦米诺及麦米诺复方)对不同病因的阴道炎有良好的影响,这使我们有理由认为该药物适用于混合形式的阴道感染。