Sacks F M
Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Am J Cardiol. 1998 Nov 26;82(10B):14T-17T. doi: 10.1016/s0002-9149(98)00717-6.
Evidence from epidemiologic studies and clinical trials have conclusively demonstrated a direct association between coronary artery disease and levels of total and low-density lipoprotein (LDL) cholesterol. Data from a number of studies suggest that even "average" or "normal" cholesterol levels are too high with respect to coronary artery disease risk. Low levels of high-density lipoprotein (HDL) cholesterol have also emerged as a coronary artery disease risk. A recent meta-analysis has eliminated much of the controversy surrounding triglyceride's contribution to coronary artery disease risk, establishing triglyceride levels as an independent risk factor. Lowering lipid levels by any means-including pharmacologic, surgical, and dietary/lifestyle changes--decreases coronary artery disease risk.
流行病学研究和临床试验的证据已确凿表明冠状动脉疾病与总胆固醇及低密度脂蛋白（LDL）胆固醇水平之间存在直接关联。多项研究的数据表明，即便“平均”或“正常”的胆固醇水平，就冠状动脉疾病风险而言也过高。高密度脂蛋白（HDL）胆固醇水平低也已成为冠状动脉疾病的一个风险因素。最近的一项荟萃分析消除了围绕甘油三酯对冠状动脉疾病风险影响的诸多争议，将甘油三酯水平确立为一个独立的风险因素。通过任何手段——包括药物、手术以及饮食/生活方式改变——降低血脂水平可降低冠状动脉疾病风险。
