Patterson R, Harris K E
J Lab Clin Med. 1978 Aug;92(2):283-9.
This study used rhesus monkeys which had consistent respiratory responses to a standard (single dose) aerosolized concentration of A. Beginning at lower concentrations of A which did not produce an airway response, fourfold increases in concentrations of A were aerosolized until an airway response occurred. Compared with the single-dose SAC after the TAC, some consistently reactive animals did not respond to the SAC, the maximal concentration of A used for testing. Thus the TAC may result in an acute form of airway desensitization. Animals vary in the threshold concentrations of A required to produce an airway response. A repeat challenge with the threshold antigen concentration during the same experiment resulted in a second response generally greater than the initial response at the same concentration. When the SAC system was similarly evaluated by repeat challenges with the same A concentration, the second response was generally less than the first. Different methods for evaluation of pharmacologic inhibitors of IgE-mediated airway responses may be developed from this rhesus model of asthma.
本研究使用了对标准（单剂量）雾化浓度的变应原A具有一致呼吸反应的恒河猴。从不会引发气道反应的较低变应原A浓度开始，将变应原A的浓度以四倍递增进行雾化，直至出现气道反应。与激发后单剂量标准激发浓度相比，一些始终有反应的动物对用于测试的最大变应原A浓度即标准激发浓度无反应。因此，激发后可能会导致一种急性气道脱敏形式。动物产生气道反应所需的变应原A阈值浓度各不相同。在同一实验中用阈值抗原浓度重复激发会导致第二次反应通常大于相同浓度下的初始反应。当用相同变应原A浓度重复激发对标准激发系统进行类似评估时，第二次反应通常小于第一次。基于这种恒河猴哮喘模型，可能会开发出评估IgE介导的气道反应的药理抑制剂的不同方法。
