Sobhani I, Brousse N, Vissuzaine C, Mcintyre E, Marmuse J P, Kahn M F, Potet F, Mignon M
Department of Gastroenterology, Bichat Claude Bernard Hospital, Paris, France.
Am J Gastroenterol. 1998 Dec;93(12):2584-6. doi: 10.1111/j.1572-0241.1998.00724.x.
We report the case of a 45-yr-old white man, investigated for chronic diarrhea, malabsorption and weight loss associated with sicca syndrome. Endoscopic and x-ray examinations showed normal macroscopic mucosa in gastrointestinal tract (GIT). Immunohistochemistry showed diffuse polyclonal T cell lymphocytes infiltrating either epithelium and lamina propria in GIT. There was no villous atrophy in the jejunum and ileum. Corticosteroids, azathioprine, and cyclosporine failed to improve symptoms. Monthly intravenous cyclophosphamide administered over 1 yr, stopped the diarrhea and weight loss. The patient is free of symptoms up to a 5-yr follow-up.
我们报告了一例45岁白人男性病例，该患者因慢性腹泻、吸收不良及与干燥综合征相关的体重减轻而接受检查。内镜检查和X线检查显示胃肠道（GIT）的宏观黏膜正常。免疫组化显示弥漫性多克隆T细胞淋巴细胞浸润GIT的上皮和固有层。空肠和回肠无绒毛萎缩。皮质类固醇、硫唑嘌呤和环孢素未能改善症状。在1年多的时间里每月静脉注射环磷酰胺，止住了腹泻和体重减轻。在长达5年的随访中，患者无症状。
