Kannan K, Latha P N, Shanmugam G
Cancer Biology Division, School of Biological Sciences, Madurai Kamaraj University, India.
Oral Oncol. 1998 Sep;34(5):373-6. doi: 10.1016/s1368-8375(98)00037-2.
Thirty-nine oral squamous cell carcinomas were assessed for bcl-2 protein expression by immunostaining of tumour sections. Twenty-three per cent of these tumours showed strong nuclear staining for bcl-2 protein. Tumours of the cheek and tongue together accounted for 77% of overexpression of this protein. When bcl-2 expression was compared with p53 expression, they were found to be non-overlapping. These results suggest that overexpression of either of these genes may substitute each other in the development of oral carcinomas of Indians.
