普拉德-威利综合征患者脑脊液中催产素水平：初步报告
Cerebrospinal fluid levels of oxytocin in Prader-Willi syndrome: a preliminary report.
作者信息
Martin A, State M, Anderson G M, Kaye W M, Hanchett J M, McConaha C W, North W G, Leckman J F
机构信息
Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA.
出版信息
Biol Psychiatry. 1998 Dec 15;44(12):1349-52. doi: 10.1016/s0006-3223(98)00190-5.
BACKGROUND
Prader-Willi syndrome (PWS) is a genetic disorder characterized by mental retardation, appetite dysregulation, and a high risk for obsessive-compulsive disorder (OCD). Microscopic abnormalities of the hypothalamus have been described in PWS, and oxytocin has been implicated in both appetite regulation and OCD.
METHODS
Oxytocin and arginine vasopressin (AVP) were measured in the cerebrospinal fluid of 5 subjects with PWS (2 male, 3 female) and in 6 normal control subjects (all female).
RESULTS
CSF oxytocin was elevated in PWS (9.2 +/- 3.9 pmol/L) as compared to normal control subjects (5.1 +/- 0.9 pmol/L, p = 0.045), a finding that was more significant when excluding male subjects from analysis (p = 0.02). AVP was not significantly different between the groups as a whole.
CONCLUSIONS
These data provide further evidence for hypothalamic and oxytocinergic dysfunction in PWS. The associations between oxytocin, appetite regulation, and obsessive compulsive symptomatology in PWS warrant further investigation.
背景
普拉德-威利综合征（PWS）是一种遗传性疾病，其特征为智力发育迟缓、食欲调节异常以及患强迫症（OCD）的高风险。PWS患者已被描述存在下丘脑微观异常，且催产素与食欲调节和强迫症均有关联。
方法
对5名PWS患者（2名男性，3名女性）和6名正常对照受试者（均为女性）的脑脊液中的催产素和精氨酸加压素（AVP）进行了测量。
结果
与正常对照受试者（5.1±0.9 pmol/L，p = 0.045）相比，PWS患者脑脊液中的催产素升高（9.2±3.9 pmol/L），当排除男性受试者进行分析时，这一发现更为显著（p = 0.02）。两组整体的AVP无显著差异。
结论
这些数据为PWS患者下丘脑和催产素能功能障碍提供了进一步证据。PWS患者中催产素、食欲调节和强迫症状之间的关联值得进一步研究。
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