Haas A
Lehrstuhl für Mikrobiologie, Biozentrum der Universität, Würzburg, Germany.
Trends Cell Biol. 1998 Dec;8(12):471-3. doi: 10.1016/s0962-8924(98)01388-9.
NSF (N-ethylmaleimide-sensitive fusion protein) was the first protein to be isolated as a crucial factor in intracellular membrane-fusion events, such as the fusion of synaptic vesicles with the presynaptic membrane during neurotransmission. Although the activation of membrane SNARE proteins for subsequent fusion is clearly a primary role of NSF, recent studies have provided surprising evidence that NSF also interacts with glutamate receptors at the postsynaptic membrane in a way that does not seem to involve SNAREs. These results suggest that NSF might act as a molecular chaperone not only on SNAREs but also of other proteins.
N-乙基马来酰亚胺敏感融合蛋白（NSF）是首个作为细胞内膜融合事件关键因子被分离出来的蛋白质，比如在神经传递过程中突触小泡与突触前膜的融合。虽然激活膜SNARE蛋白以进行后续融合显然是NSF的主要作用，但最近的研究提供了惊人的证据，表明NSF还以一种似乎不涉及SNARE的方式与突触后膜上的谷氨酸受体相互作用。这些结果表明，NSF可能不仅作为SNARE的分子伴侣，还作为其他蛋白质的分子伴侣发挥作用。
