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From peptides to peptidomimetics: design of nonpeptide ligands for major histocompatibility proteins.

作者信息

Krebs S, Rognan D

机构信息

Department of Pharmacy-ETH Zurich, Switzerland.

出版信息

Pharm Acta Helv. 1998 Dec;73(4):173-81. doi: 10.1016/s0031-6865(98)00021-1.

DOI:10.1016/s0031-6865(98)00021-1
PMID:9861866
Abstract

The ever increasing data available on antigen presentation by class I or class II histocompatibility proteins have made these glycoproteins highly interesting pharmaceutical targets for either vaccination or immunosuppressive therapy of autoimmune diseases and cancers. Herewith, we review the design and biological properties of the very first nonpeptide ligands of major histocompatibility proteins as well as their potential application in vaccination, Major Histocompatibility Complex (MHC) blockade or T cell receptor antagonism.

摘要

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