Olsen C G, Clasen M E
Department of Family Medicine, Wright State University School of Medicine, Dayton, Ohio, USA.
Am Fam Physician. 1998 Dec;58(9):2068-74.
Senile dementia of the Binswanger's type is a term used to describe a dementia syndrome characterized by onset in the sixth or seventh decade of life, subcortical neurologic deficits, psychiatric disorders and evidence of hypertension or systemic vascular disease. The status of senile dementia of the Binswanger's type as a distinct entity is a matter of some controversy. The array of neuroimaging abnormalities and clinical findings attributed to this condition overlap with a number of other neuropathologies. Leukoaraiosis, or attenuation of subcortical white matter, seen on computed tomographic scans or magnetic resonance imaging of the brain, is a hallmark of senile dementia of the Binswanger's type. The clinical findings associated with Binswanger's disease are varied but typically include a progressive dementia, depression and "subcortical" dysfunction such as gait abnormalities, rigidity and neurogenic bladder. Treatment is largely supportive and includes a discussion about advanced directives, social support and antidepressant therapy. Control of hypertension and aspirin prophylaxis may help prevent further progression of white matter disease.
宾斯旺格型老年痴呆症是一个用于描述痴呆综合征的术语，其特征为发病于人生的第六或第七个十年，存在皮质下神经功能缺损、精神障碍以及高血压或系统性血管疾病的证据。宾斯旺格型老年痴呆症作为一种独特疾病的地位存在一定争议。归因于这种病症的一系列神经影像学异常和临床发现与许多其他神经病理学情况重叠。脑白质疏松，即在脑部计算机断层扫描或磁共振成像上看到的皮质下白质衰减，是宾斯旺格型老年痴呆症的一个标志。与宾斯旺格病相关的临床发现多种多样，但通常包括进行性痴呆、抑郁以及“皮质下”功能障碍，如步态异常、僵硬和神经源性膀胱。治疗主要是支持性的，包括关于预先指示、社会支持和抗抑郁治疗的讨论。控制高血压和使用阿司匹林预防可能有助于防止白质疾病的进一步发展。
