Kim T K, Im J G, Kim S H, Won H J, Seo J B, Yeon K M, Han M C
Department of Radiology, Seoul National University College of Medicine, Korea.
Acad Radiol. 1998 Dec;5(12):822-31. doi: 10.1016/s1076-6332(98)80241-9.
The authors evaluated changes of lung attenuation in pigs, with special attention to the mosaic pattern of low attenuation, at thin-section computed tomography (CT) after obstruction of the proximal pulmonary artery with a detachable balloon.
In seven pigs, nine sites of the descending pulmonary artery were obstructed with detachable balloons. This-section CT scans of the lungs were obtained immediately (n = 9) and at 1 week (n = 5), 2 weeks (n = 1), 3 weeks (n = 2), 4 weeks (n = 1), 6 weeks (n = 1), 8 weeks (n = 1), and 12 weeks (n = 1) after pulmonary artery obstruction.
No statistically significant difference was found between the measured lung attenuation of the normal lung and that of the lung distal to the obstruction. Of the nine sites of pulmonary artery obstruction, five (56%) showed an irregular area of increased lung attenuation without lobular architecture. The diameter of the pulmonary artery after obstruction, compared with the diameter before obstruction, decreased by a range of 13%-57% (mean, 35%) and by 0-67% (mean, 44%) at levels 1 cm and 2 cm distal to the obstruction, respectively.
This experimental study reveals that regional low-attenuation areas do not develop for up to 12 weeks after the obstruction of proximal pulmonary artery, despite a marked decrease in the diameter of the pulmonary artery distal to the obstruction.
作者评估了猪肺部衰减的变化，特别关注在使用可分离球囊阻塞近端肺动脉后，薄层计算机断层扫描（CT）上的低衰减马赛克模式。
在7头猪中，使用可分离球囊阻塞了9个降肺动脉部位。在肺动脉阻塞后立即（n = 9）、1周（n = 5）、2周（n = 1）、3周（n = 2）、4周（n = 1）、6周（n = 1）、8周（n = 1）和12周（n = 1）获得肺部的薄层CT扫描。
正常肺与阻塞远端肺的测量肺衰减之间未发现统计学上的显著差异。在9个肺动脉阻塞部位中，5个（56%）显示出肺衰减增加的不规则区域，无小叶结构。与阻塞前相比，阻塞后肺动脉直径在阻塞远端1 cm和2 cm处分别减小了13% - 57%（平均35%）和0 - 67%（平均44%）。
本实验研究表明，尽管阻塞远端肺动脉直径明显减小，但近端肺动脉阻塞后长达12周内未出现区域性低衰减区域。
