Sasaki M, Plate K H
Department of Neuropathology, Freiburg University Medical School, Germany.
Ann Oncol. 1998 Nov;9(11):1155-66. doi: 10.1023/a:1008488709359.
Recent advances in molecular tumor biology and gene technology have provided the possibility to treat patients with malignant brain tumors by altering gene expression in tumor cells. Tumor development and progression involves alterations in a wide spectrum of genes, therefore a variety of gene therapy approaches for malignant gliomas have been proposed. In this review article, we discuss some principles of current gene therapeutic strategies that are under investigation in laboratories and in clinics. In addition, some general issues that remain to be resolved for clinical application of gene therapy in patients with malignant gliomas will be addressed.
分子肿瘤生物学和基因技术的最新进展为通过改变肿瘤细胞中的基因表达来治疗恶性脑肿瘤患者提供了可能性。肿瘤的发生和发展涉及多种基因的改变，因此已经提出了多种针对恶性胶质瘤的基因治疗方法。在这篇综述文章中，我们讨论了目前正在实验室和临床研究中的基因治疗策略的一些原则。此外，还将探讨在恶性胶质瘤患者中应用基因治疗临床时仍有待解决的一些一般性问题。
