Guertin P A, Hounsgaard J
Department of Medical Physiology, Division of Neurophysiology, Panum Institute, University of Copenhagen, 2200-DK Copenhagen N, Denmark.
J Neurophysiol. 1998 Dec;80(6):3380-2. doi: 10.1152/jn.1998.80.6.3380.
NMDA-induced intrinsic voltage oscillations depend on L-type calcium channels in spinal motoneurons of adult turtles. J. Neurophysiol. 80: 3380-3382, 1998. In a slice preparation from adult turtles, bath-applied N-methyl-D-aspartate (NMDA) induced rhythmic activity in spinal motoneurons. The underlying intrinsic oscillation in membrane potential was revealed in the presence of tetrodotoxin (TTX). NMDA-induced rhythmicity, in the presence or absence of TTX, was abolished or reduced by NMDA receptor antagonists and by three different classes of antagonists for L-type calcium channels. It is suggested that both NMDA receptor channels and L-type calcium channels contribute to NMDA-induced intrinsic oscillations in mature spinal motoneurons.
N-甲基-D-天冬氨酸（NMDA）诱导的内在电压振荡取决于成年海龟脊髓运动神经元中的L型钙通道。《神经生理学杂志》80: 3380 - 3382, 1998年。在成年海龟的脑片标本中，浴用N-甲基-D-天冬氨酸（NMDA）可诱导脊髓运动神经元产生节律性活动。在存在河豚毒素（TTX）的情况下，膜电位的潜在内在振荡得以显现。NMDA受体拮抗剂以及三类不同的L型钙通道拮抗剂，均可消除或降低在有或没有TTX存在时NMDA诱导的节律性。这表明NMDA受体通道和L型钙通道都参与了成熟脊髓运动神经元中NMDA诱导的内在振荡。
